Autonomic Assessment and Management in Sports-Related Concussion.
Autonomic dysfunction, or dysautonomia, is increasingly being recognized as a complication of concussion. While the symptoms can overlap with other postconcussion sequelae, it is important to distinguish the patient suffering from postconcussion dysautonomia in order to provide proper symptomatic ma…
Non-suicidal self-injury and suicide attempts among individuals seeking assessment for Ehlers-Danlos Syndromes.
Individuals with Ehlers-Danlos Syndromes (EDS) and Generalized Hypermobility Spectrum Disorder (G-HSD) experience psychological distress and are at an increased risk for suicidal behaviors. The current study examined associations between factors uniquely relevant to this population and prior suicide…
Assessment of internal consistency reliability and concurrent validity of PROMIS® dyspnea characteristics v1.0, PROMIS® dyspnea functional limitations 10a, and PROMIS® global health v1.2 in a dysautonomia cohort.
Dyspnea, or shortness of breath, is frequently reported among individuals with autonomic nervous system dysfunction, or dysautonomia. Currently, there are no validated dyspnea-specific patient-reported outcome measures for this population. We conducted a patient-reported outcomes study to evaluate t…
MRI Brain Imaging Patterns in Acute Intermittent Porphyria: A Retrospective Observational Study with Clinico-Radiological Correlation.
The CNS imaging manifestations of acute intermittent porphyria (AIP) are poorly systematized. We aimed to characterize the spectrum of MRI brain findings and evaluate the association between dysautonomia, CNS findings, and enteric manifestations. We retrospectively identified patients with biochemic…
Physiotherapy-integrated yoga and mindfulness plus home exercise versus home exercise alone for individuals with fibromyalgia syndrome (PhYoMind): study protocol of a randomised controlled clinical trial.
Fibromyalgia syndrome (FMS) is a chronic condition characterised by the presence of complex multiple symptoms, often accompanied by psychiatric comorbidities and sleep problems. The wide spectrum of symptoms and comorbid problems complicates treatment and management of the ensuing disability and sym…
Dysregulated Cardiovascular Autonomic Responses to Orthostatic Challenge in Mild Traumatic Brain Injury.
Mild traumatic brain injury (mTBI) often presents with symptoms of dizziness, headache, and brain fog. Prior work has linked these symptoms to impaired autonomic nervous system function and associated changes in cerebral blood flow after mTBI. Arterial baroreflex function is central to the regulatio…
Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19: in vivo evidence of structural autonomic dysfunction.
Dysautonomia has been increasingly recognized as a key feature of Long-COVID-19, potentially contributing to persistent gastrointestinal and systemic symptoms. Reduced vagal activity observed in these patients may reflect structural damage to autonomic fibers. We hypothesized that dysautonomic manif…