Patient reports of evaluations for interstitial lung disease in patients with connective tissue diseases and rheumatoid arthritis: an international survey.
Connective tissue diseases (CTDs) and rheumatoid arthritis (RA) share the pulmonary complication of interstitial lung disease (ILD). However, real-world data on patient perspectives and experience regarding screening and evaluations for ILD following CTD/RA diagnosis are limited. We conducted an int…
Systemic Autoimmune Rheumatic Disease-Associated Interstitial Lung Disease: A Pulmonary Perspective on Recent Guidelines.
Systemic autoimmune rheumatic disease-associated interstitial lung disease (SARD-ILD) represents a heterogeneous group of pulmonary disorders with substantial effects on morbidity and mortality. The clinical course varies according to the underlying rheumatic disease, radiological phenotype, extent…
Single-Dose Nivolumab as a Trigger of Myocarditis, Myositis, and Myasthenia Gravis Overlap Syndrome With Late Cardiac Death Despite Initial Recovery: A Case Report.
BACKGROUND Immune checkpoint inhibitors (ICIs) have transformed the treatment of advanced malignancies but can cause life-threatening immune-related adverse events. Myocarditis, myositis, and myasthenia gravis (MMM) overlap syndrome is a rare, highly morbid complication with high mortality. Most cas…
Severe Cardiac Involvement in a Young Woman with Mixed Connective Tissue Disease Complicated by Macrophage Activation Syndrome.
Reports of severe mixed connective tissue disease (MCTD) or macrophage activation syndrome (MAS)-associated cardiac involvement are limited. A 37-year-old woman with MCTD was transferred to a local hospital with fever and headache. She was diagnosed with meningitis and treated with glucocorticoid (G…
Rapidly Progressive Triple M Overlap Syndrome After Immune Checkpoint Inhibitor Therapy.
Immune checkpoint inhibitors (ICIs) are widely used in cancer treatment, but can cause immune-related adverse events affecting multiple organ systems. Triple M overlap syndrome (TMOS) is a rare and often fatal complication, consisting of the triad of ICI-mediated myositis, myocarditis, and myastheni…
Anti-PM/Scl antibody-positive myositis with muscle pathology resembling anti-synthetase syndrome.
Anti-PM/Scl antibodies were originally thought to be autoantibodies associated with overlap syndromes involving idiopathic inflammatory myopathies (IIM) and systemic sclerosis (SSc), but some patients with these antibodies present with clinical features similar to those of anti-synthetase syndrome (…
Nailfold Videocapillaroscopy in Pediatric Rheumatology: Established Roles, Emerging Applications, and Future Perspectives.
Nailfold videocapillaroscopy (NVC) provides direct, non-invasive access to the peripheral microcirculation and has become a central tool in adult rheumatology. Its primary clinical value lies in the evaluation of patients presenting with signs of Raynaud phenomenon (RP) and scleroderma-spectrum diso…
Impact of systemic autoimmune diseases in maternal, fetal and neonatal outcomes in Spain.
Pregnancy in autoimmune disease is increasingly feasible but carries heterogeneous maternal and perinatal risks beyond hypertensive disorders. We aimed to quantify disease-specific risks of maternal, fetal and neonatal outcomes across autoimmune diseases in a nationwide cohort, explicitly distinguis…