International development of a lupus-specific instrument to assess cognitive symptoms in patients with SLE: Lupus Brain Fog Severity Scale (LBFSS) study.
Cognitive symptoms such as 'brain fog' are frequent and disabling in patients with SLE. We aimed to develop and validate the Lupus Brain Fog Severity Scale (LBFSS), the first patient-reported outcome measure (PROM) for cognitive symptoms in SLE. The LBFSS was developed using a multi-step internation…
Photovoice Methods Pilot Study of Cognitive Impairment in Multiple Sclerosis.
Cognitive impairment (CI) affects upwards of 70% of people with multiple sclerosis (MS) and influences daily living and quality of life. Standard assessments capture performance but provide limited insight into how cognitive changes are experienced. Photovoice may help surface these internal and les…
Role of Occupational Therapy for Persons Experiencing Long COVID: A Rapid Review.
BackgroundIndividuals with long COVID experience persisting symptoms that affect daily life, particularly functional performance. Occupational therapists are well positioned to support this population given their expertise across broader health domains.PurposeThis rapid review describes the existing…
Macrophagic myofasciitis associated with transferrin receptor 2 and solute carrier family 40 member 1 variants and iron dysregulation: a case report.
Macrophagic myofasciitis (MMF) is a rare inflammatory muscle disease linked to the long-term persistence of aluminum-based adjuvants in macrophages. Its clinical spectrum includes fatigue, myalgia, and cognitive impairment, and genetic susceptibility has been suggested. To our knowledge, this is the…
Melatonin Effects on PI3K/Akt Pathway and Cognitive Function in Hypoxic Rat Hippocampal Neurons.
This study aims to investigate whether melatonin improves cognitive dysfunction in rats, induced by intermittent hypoxia, by modulating the PI3K/Akt signaling pathway, using an intermittent hypoxia animal model. Sixty-four male Wistar rats were randomly assigned to the following groups: normoxic con…
Cannabinoids for Neuropathic Pain: A Pharmacological Review of Mechanisms, Clinical Translation, and Future Directions.
Neuropathic pain (NP) continues to be a significant clinical issue because the existing treatment modalities have very low efficacy and tolerability. An increasing body of mechanistic and translational data is identifying the endocannabinoid system (ECS) as a key regulator of nociceptive transmissio…
Dysregulated Cardiovascular Autonomic Responses to Orthostatic Challenge in Mild Traumatic Brain Injury.
Mild traumatic brain injury (mTBI) often presents with symptoms of dizziness, headache, and brain fog. Prior work has linked these symptoms to impaired autonomic nervous system function and associated changes in cerebral blood flow after mTBI. Arterial baroreflex function is central to the regulatio…
Post-hospitalized Health Conditions of Covid-19 patients: A Cross-sectional study in Bangladesh.
The objective of this research is to examine comorbidity status of hospitalized Covid-19 patients and its association with post-Covid-19 health complications. Data were collected from 1207 Covid-19 patients who were hospitalized at Dhaka Medical College Hospital (DMCH), Bangladesh from May 2020 to A…