Triptolide loaded cerium oxide nanozyme based oral nanoplatform for targeted colitis therapy.
Ulcerative colitis (UC) is a type of colonic inflammation characterized by immune dysregulation and intestinal inflammation. Cerium oxide (CeO₂) nanozyme can effectively downregulate reactive oxygen species (ROS), but it lacks anti-inflammatory and other pharmacological activities. Triptolide…
Abnormal expression of galectins and their correlation with fibrogenesis in adenomyosis.
This cross-sectional study investigated galectin-1, -3, and -9 in adenomyosis. Analysis of hysterectomy tissues from premenopausal women via western blot, qPCR, immunohistochemistry, and Masson's staining revealed significantly elevated galectin levels compared to controls. Galectin expression posit…
Commensal microbiota-coated biohybrid implants induce antibiofilm, osteogenic, and immunomodulatory responses in a human 3D immunocompetent model.
Medical devices have revolutionized patient care; however, their abiotic surfaces remain highly susceptible to bacterial biofilm formation, enabling immune evasion and antibiotic resistance. Although antibacterial coatings can mitigate bacterial colonization, many rely on antimicrobial agents that m…
Biomimetic M2 exosome-based dual-drug nanoplatform for combined immunomodulation and bone protection in rheumatoid arthritis.
The current treatment of rheumatoid arthritis (RA) remains limited by severe drug-associated side effects and poor suppression of bone erosion. Herein, we report the development of biomimetic nanoparticles (CEC NPs) that co-deliver celecoxib (CXB) and the lysine-specific demethylase 1 (LSD1) inhibit…
Idiopathic IgG4-negative perivascular fibrosis with extensive thoracic aortic, coronary artery, and supra-aortic branch involvement: A case report.
Perivascular fibrosis is an uncommon fibroinflammatory disorder characterized by circumferential soft-tissue thickening surrounding the aorta and its major branches. Involvement of the thoracic region and supra-aortic branches is less common, potentially leading to imaging studies that can resemble…
Functional characterization of a biallelic MIPEP variant associated with global developmental delay, infantile epileptic spasms syndrome, and hypotonia.
The mitochondrial intermediate peptidase (MIP) catalyzes the post-import removal of an N-terminal octapeptide from a subset of nuclear-encoded mitochondrial proteins. While the mechanistic role of this processing remains unclear, biallelic MIPEP variants have been linked to respiratory chain dysfunc…
Pharmacological targeting of the TLR8/AP-1 axis ameliorates scleroderma skin inflammation and fibrosis by suppressing monocyte-mediated endothelial injury.
Toll-like receptor 8 (TLR8) is implicated in systemic sclerosis (SSc) pathogenesis, but its precise cellular mechanisms remain elusive. This study elucidates TLR8's role in monocyte-endothelial crosstalk and evaluates the therapeutic potential of targeting the TLR8/AP-1 axis in SSc. TLR expression i…
FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review).
Rheumatoid arthritis (RA) is an inflammatory, systematic and articular autoimmune disease characterized by progressive cartilage degradation and bone erosion, leading to irreversible joint deformity. Fibroblast growth factor receptor 1 (FGFR1) is a key mediator of RA‑associated bone loss. Wit…