Complications and Management of Ehlers-Danlos Syndromes and Hypermobility Spectrum Disorders: A Literature Review.
Ehlers-Danlos syndrome (EDS) is a group of inherited disorders affecting collagen and extracellular matrix proteins, which can cause skin hyperelasticity, joint hypermobility, atrophic scarring, and blood vessel fragility. Complications include joint dislocation, chronic pain, fatigue, functional ga…
Real-world all-cause healthcare resource utilization and costs among patients with interstitial cystitis/bladder pain syndrome in the United States.
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a persistent and heterogeneous condition diagnosed by exclusion, defined by a bladder-associated unpleasant sensation (e.g. pain, pressure, or discomfort), and affecting patients' quality of life. This real-world study aimed to describe all-cau…
Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
Sex-specific molecular signatures in persistent pain after whiplash injury: an exploratory analysis.
Whiplash-associated disorder grade II (WADII) is characterised by persistent pain in the absence of frank nerve injury, yet its molecular mechanisms remain unclear. To identify molecular signatures of 2 recovery groups characterised by persistent moderate/severe and minimal symptoms in WADII using R…
From compression to denervation: Multimodality imaging of cervical rib-related arterial thoracic outlet syndrome.
Thoracic outlet syndrome (TOS) encompasses a spectrum of disorders caused by compression of neurovascular structures at the thoracic outlet. Arterial thoracic outlet syndrome (aTOS) is rare, accounting for less than 1% of cases, yet carries significant morbidity due to arterial injury, thrombosis, a…
Patient Experiences and Preliminary Effects of Virtual Reality Based Pain Treatment in Rheumatoid Arthritis Patients With Persistent Pain Despite Low Disease Activity: A Mixed Method Pilot Study.
This study aimed to examine the acceptability, usability, patient perceptions and preliminary effects of a virtual reality (VR) based pain management programme for people with rheumatoid arthritis with persistent pain despite low disease activity. This study used a two-phase mixed-methods approach w…
Mesotherapy With Lidocaine and Ketamine in Complex Regional Pain Syndrome Type 1: A Randomized Double-Blind Trial.
Complex regional pain syndrome type 1 (CRPS1) is a disabling pain syndrome whose treatment remains challenging. Mesotherapy is a therapeutic method involving the injection of low doses of active substances through the skin. No studies assessed mesotherapy in CRPS1 patients. The aim of this study was…
Unraveling the regulatory mechanisms of tetrandrine in microglial phenotypic transition and neuronal autophagy for relieving diabetic neuropathic pain.
Diabetic neuropathic pain (DNP) is a prevalent and debilitating complication of diabetes mellitus, characterized by persistent pain and neuroinflammation. Current treatments often provide inadequate relief, highlighting the need for novel therapeutic strategies targeting its underlying mechanisms. T…