Exploring oxidative and antioxidant biomarkers in temporomandibular joint disorders: An exploratory systematic review across multiple biological fluids.
To determine if oxidative stress markers are consistently altered in TMD patients compared to healthy controls, by synthesizing evidence from blood, saliva, and synovial fluid analyses and assessing study quality. Following PRISMA guidelines, Medline/PubMed, Scopus, Web of Science, Google Scholar, C…
Factors predicting health-enhancing physical activity in patients with chronic widespread pain following a person-centred health plan.
Regular physical activity improves symptoms and overall health in people with chronic widespread pain. However, many struggle to stay active over time, highlighting the need for strategies that support long-term physical activity. To investigate if person-centred health plans that include physical a…
Global disparities in association between leisure-time physical activity and chronic musculoskeletal pain: A systematic review and meta-analysis.
Previous studies have extensively investigated the association between leisure-time physical activity (LTPA) and chronic musculoskeletal pain (CMSP). However, the results have been inconsistent. It is not known whether the differences in the association between LTPA and CMSP are due to underlying fa…
Efficacy analysis of combined nerve combing and decompression for occipital neuralgia based on the classification of neurovascular relationships.
This study set occipital pain improvement as the primary endpoint, and overall headache relief, migraine index, medication use and complication rate as secondary endpoints, to evaluate the efficacy and safety of neural combing plus decompression guided by four neurovascular relationship subtypes for…
From compression to denervation: Multimodality imaging of cervical rib-related arterial thoracic outlet syndrome.
Thoracic outlet syndrome (TOS) encompasses a spectrum of disorders caused by compression of neurovascular structures at the thoracic outlet. Arterial thoracic outlet syndrome (aTOS) is rare, accounting for less than 1% of cases, yet carries significant morbidity due to arterial injury, thrombosis, a…
Integrating Nonpharmacologic Strategies for Pain with Inclusion, Respect, and Equity (INSPIRE): Cultural and linguistic tailoring for a digital health intervention.
Chronic pain (CP) disproportionately affects underserved populations who often experience barriers to evidence-based nonpharmacologic treatments. Digital health interventions can address these barriers by providing scalable and accessible CP management resources. However, culturally and linguistical…
Initial efforts of translational development of AAV-encoded NaViPA1 for peripherally targeted analgesia in neuropathic pain.
We previously reported the discovery of a multipronged sodium channel-inhibitory peptide aptamer (NaViPA1), derived from the intracellular disordered sequence conserved among tetrodotoxin-sensitive (TTXs) sodium channels (NaVs), for adeno-associated virus (AAV)-mediated sensory neuron-targeted analg…
Passive recharge burst spinal cord stimulation for the treatment of refractory nonsurgical low back pain: 24-month results from a prospective randomized controlled trial and predictors of success.
Spinal cord stimulation (SCS) is an established treatment for chronic pain, but long-term results are limited. The objective of this manuscript was to evaluate the 24-month durability of outcomes for patients with nonsurgical refractory chronic low back pain (NS-CLBP) treated with implanted burst SC…