TRANSformative perspectives on endometriosis research policy, and practice: Insights from multidisciplinary focus groups.
Transgender and gender diverse (TGD) people with endometriosis have unique health needs. Current health research, policy, and clinical practice are developed within a biomedical and cisheteronormative paradigm that structurally excludes the TGD community, whose health needs remain largely unmet. Thi…
Prevalence and Impact of Pelvic Floor Dysfunction in a Large Cohort of Patients with Endometriosis: The Hidden Link
A survey of 525 women with confirmed endometriosis found pelvic floor dysfunction in the large majority: 83.8% reported sexual dysfunction, 65.9% moderate-to-severe urinary symptoms, and 66.3% moderate-to-severe bowel symptoms. The authors describe this as an underdiagnosed and undertreated part of…
Imaging of Deep Endometriosis Involving Lateral Pelvic Structures.
Deep endometriosis affecting the lateral pelvic structures (LPS) is a complex and often underdiagnosed manifestation of the disease. The authors review the anatomic features of the LPS and underscore the importance of MRI in detecting lesions and assessing neurovascular involvement. A solid understa…
[Endometriosis pain research in Germany : ENDO-PAIN and StEPP-UPP-two new research consortia on endometriosis pain].
Endometriosis is one of the most common causes of chronic pelvic or lower-abdominal pain, yet mechanisms, predictors, and patient-centered treatment pathways remain insufficiently defined. This article summarizes the situation in Germany and presents two complementary research consortia: StEPP-UPP a…
Adhesive Versus Spatial Anatomical Distortion Determines Energy Device Performance in Complex Total Laparoscopic Hysterectomy.
To evaluate whether the type of anatomical distortion-spatial or adhesive-determines the relative performance of the energy device in complex total laparoscopic hysterectomy (TLH). Retrospective cohort study. Single tertiary referral center. A total of 167 women who underwent complex TLH between 201…
Generation and Characterization of a Rdh1-iCre Line to Study Uterine Glandular Biology.
The uterus is an essential organ for fetal development in most mammals. Uterine glands, highly conserved structures in the mammalian uterus, play critical roles in the establishment and maintenance of pregnancy and have been implicated in the pathogenesis of uterine diseases, including endometrial c…
Beyond antioxidant activity, toward redox modulation: N-acetylcysteine (NAC) in endometriosis and uterine leiomyomas.
Endometriosis and uterine leiomyomas are common chronic gynecologic diseases associated with immune dysregulation, inflammation, and aberrant cellular proliferation, processes that contribute to increased oxidative stress. Current management relies largely on surgical and hormonal interventions, hig…
Alterations in Cellular Immunity in Patients With Endometriosis: Systematic Review and Meta-Analysis.
Determining the pathogenesis of endometriosis remains a major challenge in contemporary gynecology, and the investigation of alterations in cellular immunity may provide important insights into this issue. A comprehensive search of electronic databases (PubMed, The Cochrane Library, ClinicalTrials.g…