Integrated single-cell and spatial transcriptomics reveal stromal-immune-vascular crosstalk in patients with interstitial cystitis/bladder pain syndrome.
Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by complex cellular heterogeneity and inflammatory dysfunction in the bladder. However, the molecular pathogenesis of IC/BPS remains poorly understood, and few studies have provided comprehensive analyses. To elucidate the mechani…
A prospective surgical evaluation of the coexistence of endometriosis and interstitial cystitis/bladder pain syndrome.
Endometriosis and interstitial cystitis/bladder pain syndrome (IC/BPS) frequently coexist; however, diagnostic delays and non-standardized criteria limit accurate identification of these conditions. To assess the feasibility, safety, and clinical characterization of coexisting endometriosis and IC/B…
Are We Missing the Bladder? Reflections on Endometriosis and IC/BPS.
Endometriosis and interstitial cystitis/bladder pain syndrome (IC/BPS) frequently coexist in women with chronic pelvic pain, yet overlapping symptoms and non-standardized diagnostic pathways often delay recognition of dual pathology. We propose that a structured surgical approach combining laparosco…
Mucoadhesive Peptide-Catalase Self-Assembled Nano-Formulation for Effective Treatment of Mucosal Inflammatory Diseases.
Mucosa, a vital interface between the body and external environment, often suffers from reactive oxygen burden within its microenvironment, leading to various mucosal inflammatory diseases. Drug delivery directly to inflamed mucosal regions offers a promising therapeutic approach, yet efficacy is co…
Optimizing the Diagnosis of Interstitial Cystitis/Bladder Pain Syndrome: An ESSIC Proposal.
Interstitial cystitis/bladder pain syndrome (IC/BPS) is a heterogenous symptom syndrome. Patients are often misdiagnosed, and current treatment algorithms do not promote an individualized approach to care. This latest international guideline from International Society for the Study of Interstitial C…
Intravesical HA/EGF Salvage Therapy for Hyaluronic Acid-Refractory Interstitial Cystitis/Bladder Pain Syndrome: A Small Retrospective Pilot Case Series.
Some patients with interstitial cystitis/bladder pain syndrome (IC/BPS) remain symptomatic despite prolonged intravesical hyaluronic acid (HA). We report a small retrospective pilot case series evaluating HA plus epidermal growth factor (HA/EGF) as salvage therapy in selected HA-refractory patients.…
Sacral Neuromodulation Test-Phase Success in Bladder Pain Syndrome: Systematic Review and Meta-Analysis.
Progression from sacral neuromodulation (SNM) test stimulation (stage 1) to permanent implantation (stage 2) is a key decision in refractory interstitial cystitis/bladder pain syndrome (IC/BPS), but conversion rates and comparisons between percutaneous nerve evaluation (PNE) and staged tined-lead te…
Exploration and experimental validation of oxidative stress-related diagnostic genes in interstitial cystitis based on transcriptomics.
Interstitial cystitis (IC) is a chronic pain syndrome with an elusive diagnosis and poorly understood pathogenesis, in which oxidative stress (OS) is increasingly implicated. This study aimed to identify and validate OS-related diagnostic biomarkers for IC using an integrative computational and expe…