Constipation with bloating: a clinical approach to evaluation and management.
Constipation and bloating are common bothersome gastrointestinal (GI) symptoms that frequently occur concurrently. It is important to recognize the underlying condition(s) and tailor therapeutic interventions appropriately. This review discusses the evaluation and management of patients with constip…
Efficacy and safety of modified Gwakjeongtang (herbal medicine) for diarrhea-predominant irritable bowel syndrome: A randomized, double-blind, placebo-controlled trial.
Irritable bowel syndrome (IBS) significantly impairs quality of life, and current treatments often provide insufficient symptom relief. Gwakjeongtang is the most frequently prescribed herbal medicine for IBS patients in Korea. We aimed to explore the efficacy and safety of modified Gwakjeongtang (mG…
Oral hydrogel systems in lower gastrointestinal disorders: From disease-based therapy to microbiota-guided design.
The lower gastrointestinal tract is a complex ecological system involved in epithelial barrier maintenance, immune regulation, microbial metabolism, and host homeostasis. Disruption of this environment is closely associated with lower gastrointestinal disorders, including inflammatory bowel disease…
Validation of IBS-GEC ESTRO-ABS Computed Tomography-Based Contouring Recommendations Using Prebrachytherapy Magnetic Resonance Imaging in Patients With Cervical Cancer Treated With Definitive Radiation Therapy.
Consensus guidelines from IBS-GEC ESTRO-ABS (Indian Brachytherapy Society- Groupe Européen de Curiethérapie - European Society for Radiotherapy and Oncology- American Brachytherapy Society) for computed tomography (CT)-based contouring have recently introduced possibilities of CT-based ada…
Early Prediction of Diabetic Macular Edema via Machine Learning Survival Analysis on Checkup Data.
To predict the risk of diabetic macular edema (DME) onset and to identify features of the risk subgroups. Population-based observational study with a case-control design. Health checkup and diagnosis data from the JMDC claims database (January 2005-July 2020), one of the largest Japanese epidemiolog…
Thoracic outlet syndrome in patients with clavicle fracture: Case report and national analysis.
Thoracic outlet syndrome (TOS) is a neurovascular condition caused by compression of the brachial plexus or subclavian vessels as they pass through the thoracic outlet. Since the clavicle border the thoracic outlet, injury to the clavicle and potentially post-traumatic callus formation, malunion, or…
Personalized survival prediction in elderly dialysis patients: integrating machine learning with traditional survival analysis.
Elderly patients undergoing kidney replacement therapy (KRT) face high mortality rates. Traditional statistical models describe overall survival patterns but may fail to capture non-linear relationships among clinical factors. This study integrates classical survival analysis and machine learning (M…
Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls.
Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders. Stool was collected from 120…