Examining Cost Differences in Malignant Brain and Central Nervous System Tumor Treatment Across US Military Health System Care Settings.
The objectives of this study were to determine whether the cost of care for malignant brain and other central nervous system tumors (MBT) in the US Military Health System differs between the Department of War-operated direct care (DC) network and the affiliated civilian-operated private sector care…
Adverse Pathological Features and Worse Prognosis in Rectal Cancer Compared With Colon Cancer in T1 and T2 Stages.
Emerging endoscopic techniques are expanding opportunities for minimally invasive therapy in early colorectal cancers (CRCs). Data regarding the clinicopathological features and outcomes of colon versus rectal cancers in Tis, T1, and T2 stages remain limited. This study evaluates and compares these…
Exploring oxidative and antioxidant biomarkers in temporomandibular joint disorders: An exploratory systematic review across multiple biological fluids.
To determine if oxidative stress markers are consistently altered in TMD patients compared to healthy controls, by synthesizing evidence from blood, saliva, and synovial fluid analyses and assessing study quality. Following PRISMA guidelines, Medline/PubMed, Scopus, Web of Science, Google Scholar, C…
Tick-borne pathogens in dogs and their ticks in France: Molecular and serological evidence from a multicenter participatory study.
Canine tick-borne diseases (TBDs) are expanding globally, representing an increasing concern for both veterinary and public health. Dogs, due to their close contact with humans and frequent exposure to ticks, may serve as valuable sentinels for zoonotic risk. Between December 2022 and December 2023,…
Platycodin D attenuates proliferation, migration, and angiogenesis in RA-stimulated endothelial cells via CD146 modulation.
To investigate the effects of Platycodin D (PD) on the proliferation, migration, and angiogenesis of EA.hy926 endothelial cells stimulated by supernatant from a rheumatoid arthritis (RA) synovial cell model (MH7A), this study aims to preliminarily explore its potential mechanisms. The TNF-α-st…
Triptolide loaded cerium oxide nanozyme based oral nanoplatform for targeted colitis therapy.
Ulcerative colitis (UC) is a type of colonic inflammation characterized by immune dysregulation and intestinal inflammation. Cerium oxide (CeO₂) nanozyme can effectively downregulate reactive oxygen species (ROS), but it lacks anti-inflammatory and other pharmacological activities. Triptolide…
Immune cell-derived membrane nanovesicles: A promethean fire for autoimmune disease therapy through immune cell mimicry.
Autoimmune diseases (AIDs) constitute a heterogeneous group of disorders characterized by immune dysregulation, loss of self-tolerance, and chronic inflammation, which leads to tissue damage and organ dysfunction. Current therapies for AIDs are often limited by their lack of specificity, systemic si…
Evaluation of long-term healthcare utilization and costs associated with COVID-19 among adults and children in the US.
This study assessed long-term healthcare resource utilization (HCRU) and direct medical costs associated with COVID-19 among adults and children in the United States. Using a large national claims database, we quantified the incremental healthcare burden during the year following a first COVID-19 di…