Tampon test measurement properties in women with provoked vestibulodynia: baseline data from a pragmatic randomized clinical trial.
Provoked vestibulodynia (PVD) is a common cause of dyspareunia in young women. Because intercourse-related pain cannot be assessed consistently in all affected women, the tampon test (TT) is often used as a standardized proxy for insertional pain. This study aimed to evaluate within-person variabili…
Topical resiniferatoxin for the treatment of vestibulodynia: a prospective observational trial.
Vestibulodynia is the most common subtype of vulvodynia and is characterized by persitent, contact-evoked pain localized to the vulvar vestibule. Increasing evidence supports a neuropathic pain mechanism in vestibulodynia, including vestibular hyperinnervation, neuroinflammation, and overexpression…
Molecular mechanisms and therapeutic perspectives in vulvodynia: From current evidence to future investigations.
Vulvodynia is defined as chronic vulvar pain persisting for at least 3 months without a clear identifiable cause. It affects 10%-16% of women, and despite its high prevalence and the severity of symptoms, vulvodynia remains significantly understudied. Here, we consolidate and analyze the scientific…
Comment on: "A cluster analysis of psychological variables to identify profiles of Nociplastic pain: A cross-sectional study in women with fibromyalgia, chronic headache and vulvodynia" by Nimbi et al. are conflating the theory with the empirics.
Bottom-Up vs Top-Down Treatment Strategies for Pelvic Venous Disorders: Comparative Analysis of Pain Relief, Recurrence, and Procedural Burden.
To compare a peripheral "bottom-up" strategy using ultrasound-guided foam sclerotherapy with a conventional "top-down" embolization strategy in women with symptomatic pelvic venous disorders (PeVD), with respect to pain relief, recurrence-free survival, and procedural burden. This was a retrospectiv…
Characterizing sexual dysfunction in females with hypermobile Ehlers Danlos syndrome or hypermobility spectrum disorder and genito-pelvic pain through cross-sectional analysis.
Joint hypermobility is associated with connective tissue disorders, hypermobile Ehlers Danlos Syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD). Affected patients have high rates of myofascial pain and mast cell dysfunction, both of which have been associated with genito-pelvic pain. To char…