Human factors validation study of a disposable autoinjector (Bmab 1200 autoinjector) for subcutaneous delivery of Ustekinumab.
Ustekinumab is approved for treating moderate to severe plaque psoriasis, psoriatic arthritis, Crohn's disease, and ulcerative colitis. The Bmab 1200 autoinjector is a simple, two-step device for subcutaneous ustekinumab biosimilar delivery. This was an in vitro, nonclinical, simulated-use human fac…
ADAR1 loss-of-function variants altering RNA editing define a new interferon-dependent psoriasis subtype.
Recent evidence implicates altered RNA editing and dysregulated type I IFN signaling in immune-mediated diseases, including psoriasis, although the underlying genetic mechanisms remain poorly defined. We investigated four unrelated multiplex families with early-onset plaque psoriasis, with or withou…
Artificial Intelligence in Musculoskeletal Imaging: Innovations and Clinical Impact in Rheumatology.
This article summarizes key advancements of artificial intelligence (AI) for rheumatic and musculoskeletal disease imaging in the diagnosis and classification, and predictive modeling of rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, and osteoarthritis since 2020. AI applications are…
Cardiovascular risk goal attainment in the United States rheumatologic population.
Rheumatologic diseases are independently linked to premature cardiovascular (CV) events. The emerging field of cardio-rheumatology addresses the intersection of inflammation and accelerated atherosclerosis driving excess CV risk. Despite calls to action, data on risk factor optimization, antihyperli…
Psychometric Properties of the Work Ability Index Among Patients With Arthritis in Singapore.
The Work Ability Index (WAI) is recommended for use among individuals with arthritis but has yet to be validated in Singapore. We therefore aimed to evaluate the psychometric properties of WAI among individuals with arthritis in Singapore and whether its first item (WAS) and a version without diseas…
Pulmonary tularemia leading to a relapse of tularemia orchitis in a patient on TNF-alpha inhibitor.
Tularemia represents a zoonotic infection that poses particular diagnostic and therapeutic challenges in immunocompromised patients. We present a rare case of tularemia orchitis in a patient receiving tumor necrosis factor alpha (TNF alpha) inhibitor treatment. We conducted a cas…
Influence of national socioeconomic status on treatment retention and disease activity in psoriatic arthritis and axial spondyloarthritis: evidence over 2 years in 13 European countries.
To explore the association between national socioeconomic indicators, and (i) 6/12/24-month retention of biologic/targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARD), and (ii) disease activity at treatment start, in patients with psoriatic arthritis (PsA) or axial spondyloarthritis…
Do DMARDs increase the risk of cancer recurrence in patients with spondyloarthritis, psoriatic arthritis and rheumatoid arthritis?
To assess whether the use of immunosuppressants after cancer diagnosis in patients with spondyloarthritis (SpA) and rheumatoid arthritis (RA) is associated with increased risk of cancer recurrence or mortality. We consecutively enrolled patients with spondyloarthritis (SpA), psoriatic arthritis (PsA…