WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.
This study explored whether Lycium ruthenicum polysaccharide (LRP) influences gut microbiota-derived short-chain fatty acids (SCFAs) and neuroinflammatory responses in a sleep deprivation-induced CFS-like mouse model. Oral LRP was associated with improved fatigue-related behavioral performance, redu…
Exploring differences in protein cargo of extracellular vesicles from ME/CFS patient plasma compared to healthy controls.
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by post-exertional malaise, fatigue and pain. Yet, its underlying biological mechanisms remain poorly understood. Extracellular vesicles (EVs) are nanoparticles carrying biological cargo a…
Macrophagic myofasciitis associated with transferrin receptor 2 and solute carrier family 40 member 1 variants and iron dysregulation: a case report.
Macrophagic myofasciitis (MMF) is a rare inflammatory muscle disease linked to the long-term persistence of aluminum-based adjuvants in macrophages. Its clinical spectrum includes fatigue, myalgia, and cognitive impairment, and genetic susceptibility has been suggested. To our knowledge, this is the…
Meta-Analysis: Chronic Gastrointestinal Symptoms and Comorbidities in Hypermobile Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders.
Patients with Ehlers-Danlos syndrome (EDS)/hypermobility spectrum disorders (HSD) report higher rates of chronic gastrointestinal (GI) symptoms, disorders of gut-brain interaction (DGBI), and extraintestinal comorbidities. We conducted a systematic review and meta-analysis to assess the prevalence o…
Exploring social moderators of telehealth treatment outcomes for adults with multiple sclerosis: A secondary analysis of a randomized controlled trial.
Relationships play a pivotal role in improving health and functioning for individuals with multiple sclerosis (MS), with social support often intertwined in self-management interventions. We explored social factors as moderators and nonspecific predictors of treatment outcomes in two telehealth inte…
Chronic stress primes TLR3-mediated systemic inflammation to produce persistent post-viral fatigue syndrome-like symptoms in mice.
This study examined the long-term effects of polyinosinic:polycytidylic acid (poly I:C), a synthetic double-stranded RNA and Toll-like receptor 3 (TLR3) agonist, on behavioral and immune outcomes in chronically stressed mice. Male C57BL/6J mice were exposed to 21 days of wet bedding stress fo…
Hyperbaric oxygen alleviates CFS-like cognitive impairment via PLA2G4A-linked glycerophospholipid metabolism.
Chronic fatigue syndrome (CFS) is frequently accompanied by persistent cognitive deficits and neuroinflammation, yet effective interventions remain limited. Here we tested whether hyperbaric oxygen (HBO) improves CFS-related cognitive impairment in mice and examined a glycerophospholipid-metabolic m…
Association between light exposure patterns and multidimensional health outcomes in individuals with myalgic encephalomyelitis/chronic fatigue syndrome: findings from an observational cross-sectional cohort study.
Light is a major environmental factor regulating circadian rhythms, sleep- wake cycles, and mood-related behaviors. Patients with Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) often experience circadian disruption and poor sleep quality, which severely compromise their quality of life;…