CCDC77 and SLC45A3 mediate the genetic mechanism of Hashimoto's thyroiditis through IL-6.
Hashimoto's thyroiditis (HT) is a common autoimmune thyroid disorder with a complex genetic background. Interleukin-6 (IL-6) has been implicated in its pathogenesis, but the genetic mechanisms remain unclear. Two-sample Mendelian randomization (MR) using expression quantitative trait loci (eQTL) and…
Association between long-term exposure to environmental coarse particulate matter and the prevalence of thyroid disorders: a cross-sectional study in China.
Evidence linking long-term exposure to particulate matter with thyroid dysfunction is increasing, but data on particulate matter 10 micrometers or less (PM10) exposure and thyroid disorders remain limited. 73,900 subjects aged ≥ 18 years from a nationwide population-based study were included.…
Artificial intelligence-based ultrasound diagnosis of Hashimoto's thyroiditis: a systematic review and meta-analysis.
Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disorder, often diagnosed using ultrasound. However, conventional gray-scale ultrasound is subject to high subjectivity and operator dependence. Artificial intelligence (AI)-assisted ultrasound has the potential to enhance diagnostic…
Coexistence of VLCAD deficiency and Hashimoto's thyroiditis: a rare case report.
Very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency is a mitochondrial fatty acid oxidation disorder caused by mutations in the acyl-CoA dehydrogenase very long chain (ACADVL) gene. Hashimoto's thyroiditis is the most common autoimmune thyroid disease. To the best of our knowledge, their coexi…
TSH receptor autoantibodies - a personal experience.
Nineteen fifty six was a pivotal year in our understanding of thyroid disease with the discovery of long acting thyroid stimulator (LATS) in the serum of patients with Graves' disease and autoantibodies to thyroglobulin in Hashimoto's disease. Soon after its discovery, LATS was shown to be a thyroid…
Sustained metabolic control in latent autoimmune diabetes in adults (LADA) with semaglutide therapy in a patient with multiple autoimmune comorbidities: a case report and literature review.
Latent Autoimmune Diabetes in Adults (LADA) is a complex form of autoimmune diabetes characterised by the presence of pancreatic autoantibodies and a progressive β-cell decline, often leading to eventual insulin dependence. Evidence supporting glucagon-like peptide-1 receptor agonists (GLP-1RA…
Autoimmune Disease Risk With GLP-1RA, DPP-4i, and SGLT2i Treatment in Patients With Diabetes.
Dipeptidyl peptidase-4 inhibitors (DPP-4i), glucagon-like peptide-1 receptor agonists (GLP-1RA), and sodium-glucose cotransporter-2 inhibitors (SGLT2i) are widely used for type 2 diabetes, yet their comparative immunologic safety is uncertain. To address this gap, we evaluated autoimmune disease inc…
Diffuse pulmonary meningotheliomatosis in a patient with autoimmune thyroiditis and chronic inflammatory disease.
Diffuse pulmonary meningotheliomatosis (DPM) is an exceedingly rare benign condition characterized by innumerable minute pulmonary meningothelial-like nodules diffusely involving both lungs. We report a 44-year-old woman with Hashimoto's thyroiditis and chronic sinusitis requiring biologic therapy,…