Immune regulatory mechanisms and potential microbiota-associated targets in Kawasaki disease: an integrative multi-omics and network pharmacology study.
Kawasaki disease (KD) is a systemic vasculitis in children primarily affecting the coronary arteries, and studies suggest that the gut microbiota may be involved in KD pathogenesis, inflammatory responses, and immune regulation. This study employed an integrative multi-omics strategy to systematical…
WIPButyrate produced by the Lycium ruthenicum polysaccharide alleviated sleep deprivation-induced chronic fatigue syndrome in mice through promoting microglial autophagy.
This study explored whether Lycium ruthenicum polysaccharide (LRP) influences gut microbiota-derived short-chain fatty acids (SCFAs) and neuroinflammatory responses in a sleep deprivation-induced CFS-like mouse model. Oral LRP was associated with improved fatigue-related behavioral performance, redu…
Functional characterization of a biallelic MIPEP variant associated with global developmental delay, infantile epileptic spasms syndrome, and hypotonia.
The mitochondrial intermediate peptidase (MIP) catalyzes the post-import removal of an N-terminal octapeptide from a subset of nuclear-encoded mitochondrial proteins. While the mechanistic role of this processing remains unclear, biallelic MIPEP variants have been linked to respiratory chain dysfunc…
Ratiometric near-infrared fluorescent probe for imaging Peroxynitrite fluxes in rheumatoid arthritis and drug-induced liver injury models.
Peroxynitrite (ONOO-) plays a pivotal role in the pathogenesis of Rheumatoid arthritis (RA) and drug-induced liver injury (DILI), with its dynamic accumulation closely associated with disease progression. To effectively monitor the level of ONOO- in biological system, fluorescent probes offer distin…
Duhuo Jisheng Decoction Mitigates Intervertebral Disc Degeneration via Metabolic Reprogramming and TGF-β/Smad-Driven Autophagy-Fibrosis Network Modulation.
Duhuo Jisheng Decoction (DHJSD) shows promise for treating intervertebral disc degeneration (IVDD), but its mechanisms concerning autophagy and fibrosis are unclear. Using network pharmacology, metabolomics, UHPLC-Q-TOF/MS, and functional studies (in vitro and in vivo), we systematically explor…
Microfluidic-based biomimetic mitochondrial nanocomposite for targeted immunotherapy of rheumatoid arthritis via mitochondrial transplantation.
Rheumatoid arthritis (RA) is a common chronic autoimmune disease and has recently been reported to be closely related to mitochondrial dysfunction. Mitochondrial dysfunction can promote the occurrence and development of rheumatoid arthritis (RA) through increased cellular ROS production, activation…
First record of Taenia krabbei Moniez, 1879, muscle cysts in roe deer (Capreolus capreolus) in Carinthia, Austria.
The present report describes the first record of the tapeworm Taenia krabbei Moniez, 1879, represented by its larval stage, in roe deer (Capreolus capreolus) from two hunting districts in Carinthia, Austria. The cysticerci of T. krabbei were found during gross meat inspection and isolated from the m…
IgM Hyposialylation Modulates Podocyte Vulnerability in Patients With Idiopathic Nephrotic Syndrome.
Altered Ig glycosylation has been implicated in antibody-mediated podocytopathies; however, the functional relevance of IgM sialylation remains poorly defined. Previous evidence suggests that circulating cationic or hyposialylated IgM may contribute to podocyte vulnerability in idiopathic nephrotic…