Examining Cost Differences in Malignant Brain and Central Nervous System Tumor Treatment Across US Military Health System Care Settings.
The objectives of this study were to determine whether the cost of care for malignant brain and other central nervous system tumors (MBT) in the US Military Health System differs between the Department of War-operated direct care (DC) network and the affiliated civilian-operated private sector care…
Environmental shaping of tolerance failure in autoimmune liver diseases: a phenotype-specific framework with primary biliary cholangitis as the strongest model.
Autoimmune liver diseases (primary biliary cholangitis, PBC; primary sclerosing cholangitis, PSC; autoimmune hepatitis, AIH) are three distinct, organ-specific autoimmune disorders that share loss of tolerance as the central pathophysiological mechanism but differ in target tissue, age of onset, gen…
Retinal organoids and stem cell therapy for vision restoration: current progress, persistent challenges, and future directions.
Vision restoration is a vital yet challenging objective in ophthalmology, as traditional therapies cannot reverse irreversible retinal damage. This issue is of significant concern, considering that millions globally are afflicted by untreatable degenerative conditions such as retinitis pigmentosa (R…
Epidemiology of primary sclerosing cholangitis in general and IBD populations: a systematic review and meta-analysis.
Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic liver condition that is closely associated with inflammatory bowel disease (IBD). PSC is associated with substantial long-term hepatobiliary morbidity, including an increased risk of cholangiocarcinoma. Reported prevalence and incidence e…
Seeing is Believing? Credibility and Behavioral Intentions Toward Evidence-Based and Misleading Health Information.
PurposeTo examine how adults respond to real-world health videos that vary in credibility.DesignRandomized, within-subjects online experiment.SettingOnline U.S. survey.Sample179 adults recruited from an online panel.InterventionParticipants viewed one misleading and one evidence-based health video,…
Latitudinal variation in morphological patterns of lens opacity among patients with cataracts.
To characterize age-related cataract (ARC) morphology and subtype distribution across Yunnan (China), Vietnam, and Sri Lanka, and to assess associations with region, age, sex, and preoperative best-corrected visual acuity (BCVA). We reviewed 390 patients (657 eyes) who underwent phacoemulsification…
Using item response theory to examine bias and the factor structure of the Pediatric Symptom Checklist-17 items among racially and income diverse youth and caregivers with Type 1 diabetes.
The use of Item Response Theory for measure development has increased over the years. Components of Item Response Theory serve as the foundation for computerized adaptive tests and can be used to ensure equitable assessment through differential item functioning (DIF) analyses across proxies of inter…